1) Jessica Collins
Don't know her name, you say? One of the creepiest guest stars, Collins, was Natalie, the Miniature Killer, back in season 7. She built meticulous little models of her crime scenes and left them for Grissom and the team to find. In the season finale, she was arrested, but not before she kidnapped Sara Sidle and left her for dead under a car in the desert. In the season 8 premiere, Grissom saved his lady.
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